These are some of the articles I have been reading on Lithium.
Standard and trace doses of Lithium: a systematic review of dementia prevention and other behavioral benefits. Mauer S et al Australian & New Zealand Journal of Psychiatry 48(9):809 2014
Lithium in both standard and trace doses appears to have biological benefits for dementia, suicide, and other behavioural outcomes. Further research of trace Lithium in dementia is warranted. It is more than warranted it is urgent! What more do you want? It reduces antisocial and suicide rates, and appears to have a biological benefit for dementia.
Calcium dysregulation and lithium treatment to forestall Alzheimer’s disease – a merging of hypotheses. Wallace, J. Cellular Calcium 55(3):175 2014
This paper provides an interesting thought. The hypothesis is that Lithium may protect against cognitive decline by stabilizing intracellular calcium through a dual synergistic mechanism of targeting both extracellular and intracellular sites by antagonizing NMDA receptors inhibiting IMP.
Would the long-time lag for development of dementia, perhaps 2 decades, and the phase of increased calcium consumption in the last 4 decades have an association?
Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer’s disease. Nunes MA et al. Current Alzheimer Research 10(1):104 2013
This data suggests the efficacy of a micro-dose Lithium treatment in preventing cognitive loss reinforcing the therapeutic potential to treat Alzheimer’s Disease using very low-doses.
Lithium and dementia: a preliminary study. Terao T et al. Progress in Neuro-Psychopharmacology & Biological Psychiatry 30(6):1125 2006.
“The findings provide partial evidence to support the contention that Lithium could offer hope as a preventive treatment for Alzheimer’s Disease.”
Journal of Trace Elements in Medicine & Biology 24th March 2017 Lithium levels in the public drinking water supply and the risk of suicide by Liaugaudaite.
This article raises a number of interesting points. The study was carried out in Lithuania and showed, like many others, that high levels of Lithium in public drinking water is associated with lower suicide rates in men but this effect was not noted in women. The article draws attention to the 800,000 annual deaths worldwide including approximately 60,00 in Europe. One often forgets that suicide is not the death of one person but a terrible tragedy for the family, friends, etc. and this may last for years causing destruction of the family unit in some cases. It is interesting that in many European countries the suicide rate is 2-4 times higher in men than in women. We draw attention to the influence of impulsiveness contributing to suicide. This short fuse syndrome (SFS) seems to be suppressed by micro Lithium in our limited experience. Does 60,000 deaths in the EU warrant supplementation of Lithium in micro amounts found in normal drinking water?