The paper Lithium: the pharmacodynamic actions of this amazing ion by Kayleigh M. Brown in Therapeutic Advances in Psychopharmacology 2013; 3(3):163 raises a number of interesting points. Perhaps the most important is the fact that Lithium works by inhibiting enzymes, with the most important being GSK-3.
At the same time, I have been catching up on my reading on the actions of tranquilizers, anti-depressants, mood modifiers, etc. and was struck by the main method of these and many other drugs like hypotensive etc. is on receptors. It seems that many cells in many conditions having one or more receptors blocked spontaneously produce more receptors and thus weaken the action of the drug. On reducing the dosage of the active drug, one gets a reverse effect. In the sense that there are a large number of active receptors without an agonist thus withdrawal might produce more symptoms than prior to treatment.
I think the above idea that cells respond to the blockade of receptors by producing more receptors is a worrying problem particularly with anti-depressants, tranquilizers, mood-modifying drugs etc. Withdrawal can cause more symptoms than the original illness. Lithium seems to work by enzyme inhibition. Luckily, inhibition of an enzyme does not seem to produce more enzymes and consequently flooding the blockage. Thus, we have GSK-3 and inositol monophosphates enzymes that control many functions that can actually be blocked without producing a by-pass effect.
It seems that GSK-3 particularly has a vast array of actions, blockade with Lithium ion seems to have many positive effects.
Like two faces of Eve, Lithium has an effect in large doses on manic depression and micro-doses (1 mg or less) have an effect on many other agents. Micro-dose levels such as are found in drinking water in many areas and has been associated with a reduction of dementia, violence, crimes, etc. Perhaps, the effect of Lithium in water is to reduce addiction and we seem to be full-speed ahead for filtered, reservoir water and we are all going to suffer from Lithium deficiency!
Actions of micro-Lithium:
· Treatment and prevention of dementia
· Ischemic heart disease and hypertension (this has been known since the last 1900’s that hard water reduces heart attacks and hypertension!)
· Spread of strokes
· Anti-drug addiction
· Love, sex, emotion
· Neurodegenerative illnesses which seem to be promoted by the activation of GSK-3
· Reduction in short fuse syndrome – over the past few decades, reaction to often minor annoyances result in violence thus short fuse syndrome is increasing
· Shown to be effective in preventing the degradation of cartilage in the prevention of Osteoarthritis!
An interesting study would be on the use of Lithium in prisons where it has great potential to reduce the build up of violence and anger. The introduction of a fountain with water containing Lithium is all that is needed.
From self observation, Lithium produces a minor tranquility but no effect on reaction time, a marked increase in memory recall, reduction of short fuse syndrome, not to mention a reduction in hypertension.
There are many things wrong with this world that was perhaps designed as a near perfect planet. The removal of Lithium in our diet or water has based on many papers from Texas, Japan, and Lithuania has been associated with increased suicide, drug addiction, crime, etc. yet we continue on this path. Never has such a simple answer to our problems been available – Lithium!
What more can you expect from a treatment costing less than $100 per year!